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- _7 value "TABLE 4 Downregulated genes in HMEC-4 cells after treatment with S100b Gene name AN Fold change Potential function -------------------------------------------------------------------------------- Stress response proteins Metallothionein 1E M10942 -2.3 Binds toxic metals and scavenges free radicals Similar to metallothionein 1E AL031602 -2.6 See function of metallothionein 1E Selenoprotein W, 1 (SEPW1) NM_003009 -2.1 Antioxidant Enzymes RNA polymerase II (DNA directed) polypeptide A NM_000937 -2.7 Largest subunit of RNA polymerase II (220 kD) Short-chain dehydrogenase reductase 1 (SDR1) NM_004753 -2.5 Regeneration of retinol (Vit. A) from retinal Highly similar to transglutaminase 2 BC003551 -2.2 99% identical to transglutaminase 2, a protein cross-linking enzyme Ubiquitin protein ligase E3A NM_000462 -2.0 Protein ubiquitination Mitochondrial proteins Glutaminase C AF158555 -2.4 Converts L-glutamine to L-glutamate Cytoskeletal-associated protein Caldesmon 1 (CALD1) NM_033157 -2.0 Actomyosin regulatory protein Other proteins RNA binding protein BRUNOL3 U69546 -2.0 Translation repression Clone 24775 AF052169 -2.1 Role unknown In contrast, the alternate RAGE ligand, S100b, triggered an increase in endothelial mRNA expression of a variety of immune-related genes." provenance.
- _7 wasQuotedFrom 14988260 provenance.