Matches in Nanopublications for { <http://www.tkuhn.ch/bel2nanopub/RA5gMIN8qk9NofvawTJPyyCJVM6-f4S89AwXwb6-iDpQw#_4> ?p ?o ?g. }
Showing items 1 to 2 of
2
with 100 items per page.
- _4 value "Adhesion of HT-29 cells on a monolayer of HUVEC pretreated with TNF? was dependent on E-selectin expression but was independent of SAPK2/p38 activity of both HUVEC and tumor cells. The adhesion of HT-29 cells to E-selectin-expressing HUVEC led to the activation of SAPK2/p38 in the tumor cells as reflected by the increased phosphorylation of the actin-polymerizing factor HSP27 by mitogen-activated protein kinase 2/3, a direct target of SAPK2/p38. Moreover, a recombinant E-selectin/Fc chimera quickly increased the activation of SAPK2/p38 in HT-29 cells. Blocking the increased activity of SAPK2/p38 of HT-29 cells by SB203580 or by expressing a dominant negative form of SAPK2/p38 inhibited their transendothelial migration." provenance.
- _4 wasQuotedFrom 11448946 provenance.