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- _6 value "binding of ligands such as FASL and TNF to FAS and the TNF receptor, respectively, induces the formation of the death-induced signalling complex (DISC) DISC in turn recruits CASP8 and promotes the cascade of procaspase activation that follows hypoxia and DNA damage induce a series of biochemical events that result in the permeabilization of the outer mitochondrial membrane, the release of cytochrome c and other pro-apoptotic molecules, the formation of the apoptosome, a large complex that contains cytochrome c, apoptotic protease activating factor 1 and caspase 9, and caspase activation" provenance.
- _6 wasQuotedFrom 15286739 provenance.