Matches in Nanopublications for { <http://www.tkuhn.ch/bel2nanopub/RA6Fh9MR05dYVIvpPkHv10ytnqgYpSKvS-XIu_AEwHk58#_5> ?p ?o ?g. }
Showing items 1 to 2 of
2
with 100 items per page.
- _5 value "The CAGA sequence is specific for Smad3/4 binding, implying that CD105 is involved in inhibition of TGF-beta1/Smad3 signalling. Furthermore, CD105 overexpression reduced serine phosphorylation of Smad3 and inhibited subsequent nuclear translocation of Smad3. CD105 resulted in high phosphorylation of JNK1, which is able to activate c-Jun. c-Jun is known to inhibit Smad3 transcriptional activity on CAGA sites, suggesting that CD105 may also inhibit Smad3 signalling through JNK1" provenance.
- _5 wasQuotedFrom 15274293 provenance.