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- _4 value "After ligand activation, the Met receptor becomes inducibly phosphorylated at multiple sites, including the major autophosphorylation sites Tyr1230/1234/1235 (homologous to Tyr361/365/366 in TPR-MET). Phosphorylation at these sites correlates with activation of the Met kinase. Using phospho-specific antibodies to Tyr1230/1234/1235, we found that SU11274 completely blocked the increase in phosphorylation (Fig. 4A, bottom)." provenance.
- _4 wasQuotedFrom 14500382 provenance.