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- _5 value "To examine whether HRG-induced membrane dynamics and beta -catenin nuclear translocation lead to increased beta -catenin/TCF�LEF signaling, we examined the effect of HRG on the transcriptional activation from a synthetic LEF/beta -catenin responsive promoter construct containing three LEF�TCF binding sites. As shown in Fig. 3A, suppression of PI 3-kinase by LY294002 or a dominant-negative mutant of the p85 subunit of PI 3-kinase (5), as well as its downstream effector AKT, was accompanied by blockade of beta -catenin nuclear signaling-associated transactivation from the LEF�TCF promoter in HRG-treated cells. " provenance.
- _5 wasQuotedFrom 11328805 provenance.