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- _4 value "from full text - We previously showed that TL1A is induced by the Fc?R signaling pathway [45]. Recently, the potential interaction of TL1A in microbial-host interaction was illustrated by a report showing microbial organisms can induce TL1A in APCs [46]. Microbial-activated TL1A was in part mediated by TLR 1, 2, 4, and 9 signaling pathways and dependent on downstream p38 MAP kinase and NF-kappaB activation (Fig. 1) [46]. Negative regulators of the TL1A signaling pathway also exist and may serve to maintain gut immune homeostasis. Our group showed that TLR8 or TLR7/8 ligand (R848) can inhibit TL1A production in a dose dependent manner [47?]." provenance.
- _4 wasQuotedFrom 19903423 provenance.