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- _5 value "SHP-2 binds to these residues on the leptin receptor via different sites [56]. Binding of SHP-2 to Y985 occurs via a SH2 domain and results in the activation of the enzyme, whereas Y974 likely associates with the active site of the enzyme SHP-2 binds to phosphotyrosine 986, becomes activated and can thus down-regulate further tyrosine phosphorylation-dependent leptin signalling such as STAT3 activation in the hypothalamus." provenance.
- _5 wasQuotedFrom 12020765 provenance.