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- _3 value "Activity of this pathway is also determined by phosphatidylinositol- 3-phosphates such as phosphatase and tensin homologue43 and the SH2 domain-containing inositol-5-phosphatase SHIP2 (ref. 44). Overexpression of these enzymes leads to decreased levels of PtdIns(3,4,5)P3. This might terminate signal transduction and/or change the nature of the phosphoinositides, altering the binding specificity to PH or phox homology domains." provenance.
- _3 wasQuotedFrom 11742412 provenance.