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- _6 value "Several kinases have been implicated in this process, including PI(3)K, Akt, glycogen synthase kinase (GSK)-3 and mammalian target of rapamycin (mTOR). Recent data indicate that obesity-induced attenuation of insulin signalling might arise from the sequential activation of protein kinase C (PKC) and inhibitor of nuclear factor-kB (IkB) kinase, although the details of this pathway have not been elucidated Knockout of PTP1B leads to increased tyrosine phosphorylation of the insulin receptor and IRS proteins in muscle and improved insulin sensitivity" provenance.
- _6 wasQuotedFrom 11742412 provenance.