Matches in Nanopublications for { <http://www.tkuhn.ch/bel2nanopub/RA72zj1p-bewzDFX0ezRzlZNMAqadgoVVZPxey2DItt1c#_7> ?p ?o ?g. }
Showing items 1 to 2 of
2
with 100 items per page.
- _7 value "In both cultured endothelial cells and blood vessels isolated from rat aorta, berberine concentration dependently enhanced phosphorylation of endothelial nitric oxide synthase (eNOS) at Ser1177 and promoted the association of eNOS with heat shock protein 90 (HSP90), leading to an increased production of nitric oxide. Furthermore, berberine attenuated high glucose-induced generation of reactive oxygen species, cellular apoptosis, nuclear factor-kappaB activation, and expression of adhesion molecules, thus suppressing monocyte attachment to endothelial cells. In mouse aortic rings, berberine elicited endothelium-dependent vasodilatations and alleviated high glucose-mediated endothelial dysfunction. All these beneficial effects of berberine on the endothelium were abolished by either pharmacological inhibition of adenosine monophosphate-activated protein kinase (AMPK) or adenovirus-mediated overexpression of a dominant negative version of AMPK. " provenance.
- _7 wasQuotedFrom 19251722 provenance.