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- _5 value "The involvement of urokinase in tissue morphogenesis is also due to its ability to stimulate the cell proliferation. A mitogenic effect of uPA has been shown for various cells; however, its mechanism remains unclear in detail and seems to vary depending on the cell type. It was originally conceived that uPA can affect mitogenesis by a direct proteolytic- or plasmin-mediated activation of latent growth factors, such as HGF, bFGF, and TGF-beta [42-45]." provenance.
- _5 wasQuotedFrom 11841347 provenance.