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- _5 value "Alternatively, Kit signaling may also activate JNK kinase, a MAP kinase activated in response to stress [35]. NF1, a GTPase activating protein, is considered to be involved in modulating Ras activation through Kit signaling [36]. NF1 deficiency that occurs in cases of neurofibromatosis may induce an increase in MAP kinase activity. Pathways with JAK/STAT or with Src family members may be involved in Kit signaling [33] (fig. 1). Some studies showed the association of JAK2 with Kit and also its activation by Kit signaling [37]. Other reports also indicated the increased activity of Lyn, a Src family member, by Kit signaling [38]." provenance.
- _5 wasQuotedFrom 15583854 provenance.