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- _4 value "Intracellular [Ca2+] increases in ischemic areas (487), partly due to overactivation of NMDA receptors; MAP2 and alpha-spectrin (fodrin) are degraded in animal models of cerebral ischemia with the calpain-specific 150-kDa alpha-spectrin fragment appearing 5 (28) or 60 min (319) after ischemia in rat brains; rate of expansion of the area of spectrin degradation is reduced by synthetic calpain inhibitors, A275 and A295 (28). Calpastatin is degraded by calpain to a membrane-bound 50-kDa polypeptide in ischemic brain (41). Tissue damage in ischemic areas involves both apoptosis and necrosis and the calpains participate in both processes" provenance.
- _4 wasQuotedFrom 12843408 provenance.