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- _3 value "IGF-1 stimulation is sufficient to induce hypertrophy of skeletal muscle [3]. For example, transgenic mice in which IGF-1 is overexpressed in skeletal muscle undergo hypertrophy [4,5]. Recently, it has been shown that IGF-1 induces hypertrophy by stimulating the phosphatidylinositol 3-kinase (PI3K)-Akt pathway, resulting in the downstream activation of proteins that are required for protein synthesis [6,7]." provenance.
- _3 wasQuotedFrom 12928036 provenance.