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- _4 value "GDNF signaling needs heparan sulphate glycosaminoglycans, such as syndecans and glypicans, probably to ensure local concentration of GDNF [26]. GDNF is able to trigger intracellular signaling events that are mediated by GFR-a but not by RET [27]. Stimulated GFR-a can trigger c-Src activation; in turn, c-Src induces phosphorylation of Met, the tyrosine kinase receptor of hepatocyte growth factor (HGF) [28]. Thus, Met may contribute to RET-independent GDNF signaling (fig. 2)." provenance.
- _4 wasQuotedFrom 15583857 provenance.