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- _7 value "DAAM1 IS REQUIRED FOR WNT/FZ/DVL ACTIVATION OF RHO We next examined whether Daam1 function is required for Rho activation by Wnt/Fz/Dvl signaling. Since either N-Daam1 or T-Daam1 disrupts the Dvl-Rho complex formation, they may represent dominant negative Daam1 mutants. Indeed, either N-Daam1 or T-Daam1, which do not induce RhoA activation, blocks RhoA activation by Wnt-1 CM, Fz, or Dvl, but not by Ephexin (Figures 3A and 3B and not shown), suggesting that Daam1 function is specifically required downstream of Dvl in Wnt/Fz activation of Rho." provenance.
- _7 wasQuotedFrom 11779461 provenance.