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- _5 value "TGF-beta raised caspase-3 activity which was blocked by BMP7 but enhanced by smad5 knockdown (Fig. 6B). Moreover, smad5 knockdown reduced the effects of BMP7. Overexpression of smad5 mimicked the effect of BMP7 on the prevention of TGF-beta-induced caspase-3 activation and further promoted the effects of BMP7 in experiments where exogenous BMP7 was added to smad5 overexpressing cells. Incubation of podocytes with high glucose (25 mM) for 24 h also enhances caspase-3 activity (Fig. 6C) which is thought to be mediated by TGF-beta" provenance.
- _5 wasQuotedFrom 17804487 provenance.