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- _2 value "Thymic tolerance depends on induction of apoptosis (programmed cell death) in immature thymocytes by antigen/MHC complexes on dendritic cells (and possibly other bone marrow-derived APCs). Interactions with antigen/MHC complexes on thymic epithelial cells promote maturation of double-positive thymocytes (CD4+CD8+CD3+TCR+) to single-positive cells (CD4+CD8-CD3+TCR+ and CD8+CD4-CD3+TCR+)." provenance.
- _2 wasQuotedFrom 1482060 provenance.