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- _4 value "Activation of NF-?B by H pylori induces nuclear translocation, which causes an increase in IL-8 messenger RNA and protein levels[50,53]. This has important implications since other NF-?B responsive genes including pro-inflammatory cytokines have been found in elevated levels in H pylori infected gastric mucosa. NF-?B activation is known to regulate cellular growth responses, including apoptosis, and is required for the induction of inflammatory and tissue-repair genes, including macrophage inflammatory protein (MIP)-2, metalloproteinase 3 (MMP3) and vascular endothelial growth factor (VEGF). The NF-?B pathway is also responsible for the generation of several cell adhesion molecules including ICAM-1 whose expression is signifi cantly correlated with an increase in H pylori induced gastritis[54]." provenance.
- _4 wasQuotedFrom 16718776 provenance.