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- _4 value "we combined the stimulation with glucose or insulin with the cotreatment with inhibitors of the insulin receptor tyrosine kinase [hydroxy-2-naphthalenylmethylphosphonic acid trisacetoxymethyl ester (HNMPA)], PI 3-kinase (wortmannin and LY294002), and mTOR (rapamycin). As shown in Figs. 1 and 2, HNMPA, wortmannin, LY294002, and rapamycin inhibited both glucose- and insulin-stimulated insulin biosynthesis in both human pancreatic islets and RIN ?-cells." provenance.
- _4 wasQuotedFrom 15001544 provenance.