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- _4 value "Upon translocation to the nucleus, the p50-p65 heterodimer NF-kappaB binds to specific kappaB recognition sites and also to coactivators, such as CREB-binding protein (CBP) or p300/CBP-activating factor (PCAF), which have intrinsic histone acetyltransferase (HAT) activity. This results in acetylation of lysines in core histone-4, resulting in increased expression of genes encoding inflammatory proteins, such as granulocyte-macrophage colony-stimulating factor (GM-CSF)." provenance.
- _4 wasQuotedFrom 16865089 provenance.