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- _6 value "CaMKIV has been shown to phosphorylate and activate many proteins, including CREB. Because CREB has been shown to be an important activator of PGC-1? gene expression in the fasted liver (24), we used the dominant-negative ACREB protein to examine a potential role for CREB in the CaMKIV-mediated control of the PGC-1? promoter. Although ACREB alone had no effect on the PGC-1? promoter, this protein severely reduced the activation of the PGC-1? promoter by CaMKIV alone or CaMKIV in combination with CnA (Fig. 1A)." provenance.
- _6 wasQuotedFrom 12764228 provenance.