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- _4 value " PtdIns(3,4)P2 and PtdIns(3,4,5)P3 are membrane-embedded and transduce signals, at least in part, by binding proteins via their specific PH or SH2 domains and recruiting them to the membrane. Examples include the PH domain-containing proteins, Akt, a serine-threonine kinase, and TIAM-1, a Rho family guanine nucleotide exchange protein; or the SH2 domain-containing proteins, phospholipase C and Src.85 In platelets, thrombin stimulates a rapid and transient increase in PtdIns(3,4,5)P3 and a later increase in PtdIns(3,4)P2." provenance.
- _4 wasQuotedFrom 9531572 provenance.