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- _5 value "In oxygenated cells, these hydroxylation reactions provide a dual mechanism of HIF inactivation that involves proteolytic destruction and inhibition of transcriptional activity (Fig.1). The HIF hydroxylases are all Fe(II)- and 2-oxoglutarate-dependent dioxygenases that have an absolute requirement for molecular oxygen, allowing HIF to escape inactivation in hypoxia." provenance.
- _5 wasQuotedFrom 12778166 provenance.