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- _5 value "The various AREs bind to a complex of nuclear proteins from cells of different origins (15-23, 25). Analysis of ARE-nuclear protein complexes have identified several nuclear transcription factors including c-Jun, Jun-B, Jun-D, c-Fos, Fra1, Nrf1, Nrf2, YABP, ARE-BP1, MafK, Ah (aromatic hydrocarbon) receptor, and the estrogen receptor (15-32). Among these transcription factors, Nrf1 and Nrf2 have been shown to heterodimerize with c-Jun and up-regulate the ARE-mediated expression and induction of NQO1 in response to antioxidants and xenobiotics (26, 31). " provenance.
- _5 wasQuotedFrom 11013233 provenance.