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- _5 value "Reporter gene analyses identified sequences between -902 and -789, including consensus Ets and interferon regulatory factor elements, required for macrophage-specific and interferon gamma-inducible transcriptional activity. Pu.1 bound to the Ets site in electromobility shift assay and forced expression of Pu.1 activated the aif-1 promoter in 3T3 fibroblasts, in which it is normally inactive. Ets family transcription factor, Pu.1 (Sfpi1), and proteins interacting with a site meeting criteria for interferon regulatory factor (IRF) binding are required for expression of the aif-1 gene in both basal and interferon-gamma (IFN-gamma )-stimulated states." provenance.
- _5 wasQuotedFrom 11861656 provenance.