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- _4 value "Dissociation of p73 and HDM2 leads to increased p73 transcriptional activity with upregulation of p73 target genes noxa, puma and p21 (RT-PCR and Western Blot) Noxa, puma and p21waf1/cip1 mRNA levels increased by 2.5-, 2.3- and 3.2- fold, respectively, following Nutlin-3 treatment (Figures 3a and b and Supplementary Figure S1" provenance.
- _4 wasQuotedFrom 17700533 provenance.