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- _6 value "Recent evidence suggests that RNF8 binds to MDC1 and ubiquitylates phosphorylated H2AX. These events facilitate the recruitment of factors (such as BRCA1 and 53BP1) that are required for DNA repair and checkpoint signalling, probably through a ubiquitin-ligase cascade98?100,102 (FIG. 2). (primary sources used as in statements)" provenance.
- _6 wasQuotedFrom 18285803 provenance.