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- _5 value "Insulin also profoundly inhibits lipolysis in adipocytes, primarily through inhibition of the enzyme hormone sensitive lipase71. This enzyme is acutely regulated by control of its phosphorylation state, which is activated by PKA-dependent phosphorylation, and inhibited as a result of a combination of kinase inhibition and phosphatase activation. Insulin inhibits the activity of the lipase primarily through reductions in cAMP levels, owing to the activation of a cAMP-specific phosphodiesterase in fat cells72." provenance.
- _5 wasQuotedFrom 11742412 provenance.