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- _4 value "ROS signals can amplify AKT signaling cascades in the forward direction through transient oxidative inactivation of the phosphatase and tensin homolog (PTEN) and other phosphatases that oppose AKT phosphorylation (21). Accordingly, we utilized the phosphorylation status of AKT as a central marker for signal transduction that can be modulated by H2O2. Accordingly, we utilized the phosphorylation status of AKT as a central marker for signal transduction that can be modulated by H2O2. Initial experiments tested the direct effects of H2O2 on AKT phosphorylation. Serum-starved control HeLa cells do not exhibit increases in pAKT/AKT ratios upon addition of H2O2 (Fig. 2D)." provenance.
- _4 wasQuotedFrom 20724658 provenance.