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- _4 value "The cells treated HGF showed significant increased and phosphorylation at tyrosine of Met, a HGF receptor. The level of tyrosine phosphorylation of Met in SP1 cells was dramatically reduced in cells within 60 min after detachment and is restored within 15 min of incubation with HGF. Met was constitutively phosphorylated at tyrosine residues in SP1 cells adhering to, and spreading on, FN substratum and shows a further increase after addition of HGF. Tyrosine phosphorylation of Met in carcinoma cells was augmented by cell adhesion and spreading on fibronectin substratum. In contrast, detached serum-starved cells exhibited reduced tyrosine phosphorylation of Met and undergo apoptotic cell death within 18 to 24 h." provenance.
- _4 wasQuotedFrom 11850817 provenance.