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- _5 value "We have discovered that the lipid-soluble thiamine derivative benfotiamine can inhibit these three pathways (the hexosamine pathway, the advanced glycation end product (AGE) formation pathway and the diacylglycerol (DAG)-protein kinase C (PKC) pathway) as well as hyperglycemia-associated NF-kappaB activation, by activating the pentose phosphate pathway enzyme transketolase, which converts glyceraldehyde-3-phosphate and fructose-6-phosphate into pentose-5-phosphate" provenance.
- _5 wasQuotedFrom 12592403 provenance.