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- _2 value "HO-1 is a cytoprotective enzyme (6) that degrades the potent prooxidant heme to generate CO and bilirubin. CO is a vasodilatory gas that has anti-proliferative effects on vascular smooth muscle cells (VSMCs) (7) and has anti-inflammatory properties (8). Bilirubin is a scavenger for reactive oxygen species (ROS) (9). In addition, ferrous ion, another product of HO-1, upregulates ferritin, which also has scavenger activity." provenance.
- _2 wasQuotedFrom 18633191 provenance.