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- _5 value "All four resistant lines contained a monoallelic point mutation in the PPAR{gamma} gene at codon 422 resulting in a change from lysine (Lys) to glutamine (Gln) (K422Q); this mutation was not found in the four sensitive cell lines (Table I). The correlation between the K422Q allele and lack of sensitivity to PPAR{gamma} ligands provided suggestive, but not definitive, evidence that this mutation caused the HCT 15, MIP 101, Clone A, and COLO 205 cell lines to be resistant to the growth inhibitory effects of PPAR{gamma} ligands." provenance.
- _5 wasQuotedFrom 12591919 provenance.