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- _4 value "The kinins are small polypeptides that are split away by proteolytic enzymes from alpha2 globulins in the plasma or tissue fluids. A proteolytic enzyme of particular importance is kallikrein, which is present in the blood and tissue fluids in an inactive form. This inactive kallikrein is activated by maceration of the blood, by tissue inflammation, or by other similar chemical or physical effects on the blood or tissues. as kallikrein becomes activated, it acts immediately on alpha2 globulin to release a kinin called kallidin that then is converted by tissue enzymes into bradykinin. Once fromed, brady kinin persists for only a few minuts because it is inactivated by the enzyme carboxypeptidase or by converting enzyme. The activated kallikrein enzyme is destroyed by a kallikrein inhibitor. Bradykinin causes both powerful arteriolar dilatation and increased capilary permeability. ...can cause marked local edema..." provenance.
- _4 wasQuotedFrom _3 provenance.