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- _6 value "Hydroxylation at two proline residues on the HIF polypeptide mediates interactions between the b-domain of the von Hippel?Lindau protein (pVHL) and HIF [60]. Each site can interact independently with pVHL, potentially contributing to the extremely rapid proteolysis of HIF-a that is observed under normoxic conditions. These sites contain a conserved LxxLAP motif and are targeted by proline hydroxylases (PHD) that, in mammalian cells, are provided by three isoforms termed PHD 1?3 [61]." provenance.
- _6 wasQuotedFrom 15350900 provenance.