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- _4 value "EDNRB reduces cyclic AMP (cAMP) production via Gai, thus leading to protein kinase A (PKA) inhibition. Since chemical PKA blockade mimics the effects exerted by ET-3 on ENS progenitors, it is likely that the RET-EDNRB interaction is mediated by PKA (fig. 1) [19]. This is supported by the finding that serine 686 in the juxtamembrane domain of RET is phosphorylated by PKA, thereby enhancing RET-mediated lamellipodia formation [20]." provenance.
- _4 wasQuotedFrom 15583857 provenance.