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- _5 value "The human interstitial collagenase (MMP-1) promoter has been also shown to be a Ras-responsive promoter by virtue of the presence of ETS and AP-1 cis-elements, which act synergistically to activate Ras-dependent transcription of the gene (15, 16). Similarly to what was observed previously with the synthetic ORE reporter, ESE-3 was able to repress the -1200 to +63 collagenase promoter response to Ras (Fig. 6B). In both cases, expression of ETS-2 resulted in enhanced expression of the reporter in these cells" provenance.
- _5 wasQuotedFrom 11259407 provenance.