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- _5 value "In agreement with this, antibody-mediated TNFR1 blockade significantly inhibited s.c. tumor growth of three independent SCC tumor lines, A431, SCC25, and CAL27 (Supplementary Fig. S8A). To determine if TNFR1 action in this context is tumor cell intrinsic, we used retroviral-mediated RNA interference to decrease TNFR1 expression. Reduced levels of TNFR1, as confirmed by immunoblotting, significantly inhibited s.c. growth of Ras-driven tumors and SCC lines (Supplementary Fig. S8B)." provenance.
- _5 wasQuotedFrom 17440097 provenance.