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- _3 value "The importance of PP1 as a CREB phosphatase is illustrated by the finding that brain-targetted genetic inhibition of PP1 in mice correlated with an enhanced learning capability that involved the hyperphosphorylation of a number of proteins, including CREB (145) (see also sect. VIIIC). In normal conditions, two additional serines that control the stability of CREB are kept dephosphorylated by PP1 (359). However, the decreased expression of PP1-gamma following hypoxia results in the hyperphosphorylation and subsequent ubiquitin-mediated degradation of CREB." provenance.
- _3 wasQuotedFrom 14715909 provenance.