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{ <http://www.tkuhn.ch/bel2nanopub/RAEDIOmGLjcvnOnoOqHN7sxEZQKC2OPSH39Md84_YF1ck#_7> ?p ?o ?g. }
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The IRS family of substrates can interact with a number of SH2 domain proteins. Notable among these is the regulatory subunit of PI 3-kinase, which leads to the activation of PIP3-dependent protein kinases such as Akt.
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