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- _5 value "p27 binds to RhoA and prevents the interaction of RhoA with its activators the guanine-nucleotide exchange factors. Fibroblasts lacking p27 have impaired migration. CIP1 binds to and inhibits Rho kinases (ROCK1 and -2) - downstream effectors of Rho. p57 (KIP2) binds to and targets LIM domain-containing protein kinase (LIMK) to the nucleus, sequestering it in a compartment where it cannot regulate the actin cytoskeleton." provenance.
- _5 wasQuotedFrom 15573116 provenance.