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- _6 value "Fig 3. HIF-1? counteracts Myc activity. (A) Effect of ?ODD on Myc transcriptional activity was examined with an hTERT luciferase reporter in HCT116 cells. .....Unlike wild-type HIF-1?, ?ODD constitutively activated HIF-1-mediated reporter gene in transient transfection (Figure 2A). We then inactivated ?ODD transcriptional activity via simultaneous mutations (L795V, C800S, L818S, and L822V) that disrupt p300/CBP binding (Gu et al, 2001; Dames et al, 2002; Freedman et al, 2002). As expected, this ?ODD LCLL mutant was unable to activate the HIF-1 reporter (Figure 2A)." provenance.
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