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- _5 value "Shapiro and colleagues (107) demonstrated that MMP-12-null mice are protected from the development of cigarette smoke-induced emphysema. Infiltrating macrophages in wild-type mice exposed to cigarette smoke might have been attracted by elastin fragments released by MMP-12, as MMP-12 knockout mice did not show evidence of increased alveolar macrophage accumulation due to chronic cigarettes smoke inhalation (124). When exposed to cigarette smoke for 2?3 days, MMP-12-null mice had an attenuated number of lung neutrophils and decreased expression of MIP-2, MIP-1{alpha}, and MMP-9 activity in BAL, suggesting that the MMP-9 response is dependent almost entirely on MMP-12 expression (180). " provenance.
- _5 wasQuotedFrom 17615396 provenance.