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- _4 value "Notch1 function in mouse skin. Representation of mammalian skin with several layers of differentiating cells, and some proteins that are expressed in specific cellular layers. After differentiation signals are received, Notch1 induces expression of involucrin, keratin-1 (K1) and the cell-cycle inhibitor Waf1, and prevents the onset of fillagrin and loricrin expression until the cell is at later stages of differentiation. Both ?-catenin-mediated Wnt signalling and Gli2-mediated Sonic-hedgehog signalling are normally repressed in the murine epidermis by Notch1. In Notch1-ablated skin, re-activation of Wnt and Sonic-hedgehog pathways result in the development of basal-cell-carcinoma-like tumours in the mouse." provenance.
- _4 wasQuotedFrom 14570040 provenance.