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- _3 value "Differentiation of human THP-1 cells into foam cells on treatment with 12-O-tetradecanoylphorbol 13-acetate (PMA) was observed in atherosclerotic lesions. When these THP-1 differentiated cells were subsequently treated with oxidized low density lipoprotein (Ox-LDL), it was observed that HB-EGF (heparin-binding epidermal growth factor-like growth factor) was highly regulated. At the end of fourth day of treatment with Ox-LDL the expression of HB-EGF was increased by 7.00-folds when compared with control. This indicates that Ox-LDL up-regulates HB-EGF in differentiated THP-1cells." provenance.
- _3 wasQuotedFrom 10973959 provenance.