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- _5 value "RET stimulation triggers many other signaling intermediates, including CREB [42], p38MAPK [42], NFkB [43], ERK5 (BMK1) [44], phosphoinositide-dependent kinase 1 (PDK1) 45, cyclin-dependent kinase 5 (CDK5) [46] and PKC isoforms [47 48] (fig. 3). Although the mechanism of activation of these pathways remains to be elucidated, Y1062 is important for most of them. In particular, Ras/ERK- and PI3K-triggering by Y1062 is essential for full activation of CREB and NFkB [42]. A novel RET interactor designated Grap-2 has been found to negatively regulate NFkB activation [43]." provenance.
- _5 wasQuotedFrom 15583857 provenance.