Matches in Nanopublications for { <http://www.tkuhn.ch/bel2nanopub/RAG7WV4ak9pHfBVyRYHbuIoQWitSeDHhHE2V8Ydzx3IeM#_4> ?p ?o ?g. }
Showing items 1 to 2 of
2
with 100 items per page.
- _4 value "Inflammation is now considered critical in the pathogenesis of myocardial infarction....We investigated whether variants of the 20S proteasome are associated with susceptibility to myocardial infarction and found a common SNP (minor allele frequency of 0.35) in the proteasome subunit alpha type 6 gene (PSMA6) conferring risk of myocardial infarction in the Japanese population (chi(2) = 21.1, P = 0.0000044, 2,592 affected individuals versus 2,851 controls)...The SNP, located in the 5' untranslated region of exon 1 in this gene, enhanced the transcription of PSMA6. Moreover, suppression of PSMA6 expression using short interfering RNA in cultured cells reduced activation of the transcription factor NF-kappaB by stabilizing phosphorylated IkappaB. " provenance.
- _4 wasQuotedFrom 16845397 provenance.