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- _5 value "A previous study by our laboratory (9) showed that emphysematous lungs express MMP-1 whereas normal adult lungs do not. To determine whether this MMP-1 expression correlated with elevated mitogen-activated protein kinase, we analyzed these same human samples for p-ERK activity. Initial experiments were performed in the absence of the specific p42/p44 (ERK) substrate to determine endogenous protein phosphorylation in normal and emphysematous lungs. No difference was detected (Fig. 5A, left). However, when specific p-ERK activity was examined, significantly higher levels were detected in lung homogenates from patients with emphysema, compared with healthy control subjects (Fig. 5A, right: 1.9 � 0.2-fold increase above normal lung, p = 0.02). We next assessed levels of ERK in eight human lung samples. Western blot analysis revealed that emphysematous lungs expressed higher p-ERK levels than normal lungs (Fig. 5B)." provenance.
- _5 wasQuotedFrom 14764579 provenance.